Implementation of a protein thermal shift chip
Announcing a new publication of review articles for Acta Materia Medica log. Traditional protein chips are based on solid chips and cannot allow detection of unlabeled drugs and targets. The authors of this paper propose a protein thermal shift chip (PTSC) based on fluorescence signals, which enables low-cost, high-throughput, and label-free screening. The authors developed a PTSC for COVID-19, containing 12 SARS-CoV-2 and host target proteins. A series of quality control tests have been carried out for small molecule drugs, macromolecular antibodies and herbal extracts. This chip has enabled high-throughput screening of COVID-19 drugs and can therefore serve as a tool for the screening of clinically effective drugs.
Article reference: Peng Chen, Zhao Cui and Caifeng Li et al. Establishing a protein thermal shift chip (PTSC) for COVID-19 and exploring the future of protein chips in pharmacology. Acta Materia Medica. Flight. 1(3):314-319. DOI: 10.15212/AMM-2022-0016
Key words: protein thermal shift chip, COVID-19, drug target, pharmacology
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